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Primary cutaneous follicle center lymphoma : ウィキペディア英語版 | Primary cutaneous follicle center lymphoma Primary cutaneous follicle center lymphoma (PCFCL) is a type of lymphoma.〔 It was recognized as a distinct disease entity in the 2008 WHO classification.〔 PCFCL had been previously conceived as a variant of follicular lymphoma (FL).〔 ==Biology== Unlike FL, PCFCL is not typically associated with t(14;18) translocation〔 although presence of that translocation does not exclude PCFCL.〔 It is usually not associated with overexpressed Bcl-2.〔 PCFCL represents about 55% to 60% of primary cutaneous B-cell lymphomas (PCBCL);〔 primary cutaneous marginal zone lymphoma and diffuse large B-cell cell lymphoma, leg type are the other primary cutaneous B-cell lymphomas.〔〔〔 The cause of PCFCL is unknown.〔 Spread from the skin is unusual, and the prognosis is excellent〔 with a 5-year survival of over 97%.〔 The International Extranodal Lymphoma Study Group identified elevated LDH, more than two skin lesions, and nodular lesions as three prognostic factors, that are used to assess a cutaneous lymphoma international prognostic index (CLIPI), which is prognostic of disease-free status.〔
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